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Prog Neuro-Psychopharmacol Biol Psychiatry 102:109958 Leclercq S et al (2021) Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms

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Additional alterations include downregulation of electron transport chain genes, TCA cycle disruption, and abnormal fatty acid metabolism

At the transcriptional level, factors like Nrf2, p53, and HIF-1 coordinate antioxidant defense and lipid metabolism to determine ferroptotic sensitivity