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Malic enzymes ME participate in reactions that link the components of catabolic metabolism in glycolysis and the Krebs cycle via the oxidative decarboxylation of malate to pyruvate, thereby inducing the anabolic metabolism with concomitant NADPH production

But in this space, the more common pattern is stacking to compensate for weak evidence, not stacking because combination efficacy is proven

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Ohkama-Ohtsu et al., 2007b)