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A membrane-free gut-on-chip study revealed that candidalysin disrupts tight junction proteins (ZO-1, occludin) to induce leaky gut, and further induces intestinal epithelial cells (IECs) apoptosis and necroptosis, thereby exacerbating barrier breakdown 111

Though squalane is often called an oil, its technically not one

Topical application must penetrate the skin barrier, and even the best formulations lose a significant portion of the active compound during that process

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They both do not contain any common allergens, parabens, silicones or sulfates