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The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells

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Zhang L et al

Nonetheless, when extracellular HSP70 is continuously elevated, it stimulates inflammation, oxidative stress, reduced expression of HSF-1, and possibly reduced intracellular HSP70 [91]

1 In contrast, glutathione levels deplete rapidly because your muscles need it during high-intensity exercise

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