The main advantage of omitting trypsin use from MS sample preparation is that peptide ends are likely to arise from endogenous protease cleavage sites, thus increasing sensitivity for identification of relevant peptide proteoforms 19
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Agarwal A, Gupta S, Sekhon L, Shah R: Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications
Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, et al