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In AD, however, tau undergoes pathological hyperphosphorylation, leading to its dissociation from microtubules, aggregation into neurofibrillary tangles, and ultimately neuronal dysfunction ( Iron overload is hypothesized to exacerbate this process through several pathways

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In response to absolute or relative depletion of NOS substrate l-arginine NOS uncoupling occurs and the uncoupled NOS generates superoxide rather than NO [69]

Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway

Recovery-related changes may take several weeks because soft tissue, tendons, ligaments, and connective tissue do not remodel overnight