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[109] Melatonin is also known to modify many cytokines, including TNF, IL1, IL-2, IL-6, and gamma-interferon, in ways consistent with increased host defense against cancers

It is naturally produced in the human body and can also be obtained through the diet, particularly through red meat and dairy products

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Finally we can also reduce 5-alpha reductase activity by decreasing total androgen production

While age and sex cannot be modified, knee OA is strongly associated with lifestyle factors that can be controlled