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The oxidative damage affects cell membranes, including those found in the respiratory epithelium and endothelial cells

10.1038/cdd.2015.158 68 XinG

Gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and rapamycin inhibition of TorC1

Standard protocols run 4-8 weeks

Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)