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Response time depends on the individual, the severity of the condition, and the dosage regimen

Perilipin-null mice also display a significant resistance to diet-induced obesity (78, 106, 127) that is explained, at least in part, by increased beta-oxidation of fatty acids, the products of lipolysis (106), following from a compensatory induction of genes involved in lipid and energy metabolism and a downregulation of genes involved in lipid biosynthesis (20)

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Higher dosages of melatonin in autism spectrum disorders would be reasonable for improving disrupted melatonin rhythms rather than low-dose melatonin administration [32,33,34], considering the findings on dysfunction of circadian rhythms and attenuation of melatonin rhythm

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