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The induction of GSTU7 and GSTF8 by SA was independent of the master regulator NPR1 gene

Gold chloride metallic salts with a 49% purity from Sigma-Aldrich was utilized for this study

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Despite a lack of direct evidence showing that FOXO4-DRI can eliminate senescent Leydig cells in aged mice, we observed that FOXO4-DRI treatment alleviates the testicular senescence phenotype, improves the testicular microenvironment, and increases serum testosterone levels, all of which could contribute to the therapeutic effects of FOXO4-DRI