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Phase 1 clinical trials are conducted in a small group (2080) of individuals to determine an investigational drugs safety and adverse effects and identify its appropriate dose

Population studies taking into account basal, absolute, and net increases of postmethionine-load homocysteine levels, in relation to dietary intake and methionine, folate, and status of vitamins B 6 and B 12 to confirm the involvement of methionine excess in both basal and postload hyperhomocysteinemia

Acta 412 , 17121724 (2011)

Knoop, A., Thomas, A., Fichant, E., Delahaut, P., Schnzer, W., & Thevis, M

H.RunhaarJ.van MiddelkoopM.et al (2019)

The most effective approach combines a consistent IV schedule with supportive nutrition and healthy habits