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The cellular and molecular changes triggered by ROS, as previously discussed, disrupt melanocyte homeostasis and contribute to pathological conditions 111
Remarkably, the modified peptides were four times more effective at generating H 2 O 2 (behaving like a SOD), but they were not neurotoxic
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For instance, ethacrynic acid has been found to be predominantly metabolised by GSTP1, whereas transstilbene oxide is a specific substrate for GSTM1 (van Bladeren, 2000)
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