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The project's critical technical bottleneck was linker selection: it needed to guarantee disulfide linker stability during blood circulation to prevent premature drug leakage, while ensuring efficient disulfide linker cleavage inside tumor cells for precise drug release

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de Koning JP, Soede-Bobok AA, Ward AC, Schelen AM, Antonissen C, van Leeuwen D, Lwenberg B, Touw IP