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Cardiovascular effects on blood pressure and vascular tone require monitoring, particularly in patients with existing cardiovascular disease or those taking cardiovascular medications

doi: 10.1093/ecco-jcc/jjae095 125 QianZ.ZhaiZ.RenM.ChengY.CaoM.WangY.et al

For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)

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[27],[28] Thus, the evidence for the clinically efficacious bioavailability of oral glutathione in humans remains scarce and controversial