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These findings are promising but have not yet translated into a licensed product

B12 supplementation in elderly patients with confirmed deficiency typically takes two main forms in the UK: Oral tablets (cyanocobalamin) Intramuscular injections (hydroxocobalamin, the standard form in the UK) NICE Clinical Knowledge Summary guidance recommends investigating B12 deficiency in older adults presenting with unexplained anaemia, neuropathy, cognitive impairment, or glossitis

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Superoxides have also been demonstrated to be an underlying cause of cytotoxicity mediated by their interactions with NO to form peroxynitrite (ONOO /ONOOH) [142,143]