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350 A global lactylome and proteome analysis profiling of a hepatitis B virus-related HCC cohort identified 9256 non-histone and 19 histone protein lactylation sites in tumors and adjacent livers, demonstrating the ubiquitous nature of lactylation in tumor biology beyond histones and transcriptional regulation
Scientific Reports, 10 (1), 1-11
( pKa values are provided next to each ionizable group.)a
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The G6PD deficiency is produced by different genetic mechanisms such as deletions, precise mutations and substitutions that affect the transcription, process or primary enzyme structure, which functionally results in a decrease of the enzymatic activity or loss of affinity by the substrate
903 In a RANKL-induced osteoclast model, the bisphosphonate zoledronic acid promotes ferroptosis by increasing Fe 2+ , ROS, and MDA levels, and decreasing GPX4 and GSH levels
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