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Subsequent iterations of the calculation will then use more restraints that are found compatible with the initial fold, thus solving ambiguities along the way

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These thiol-dependent enzymes include NADPH-dependent disulfide reductases (Gor, Mtr, YpdA) and related glutaredoxin-like enzymes (Grx, Mrx, Brx), DinB-family S -transferases (Gst, Mst, BstA), S -conjugate amidases (Mca, Bca) and glyoxalases (GloAB, GlxAB)

Your diet is another major factor