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In zebrafish, 90-day exposure to Polyactic Acid (PLA) and Aged Polyactic Acid (APLA) MPs (120 mg/L) suppressed 5-HT and DA, decreased acetylcholinesterase activity in the brain and gut and downregulated BDNF/TrkB signaling, coinciding with neuronal apoptosis

Lavrentiadou SN, Sapanidou V, Tzekaki EE, Margaritis I, Tsantarliotou MP

Indeed, sulfasalazine (which inhibits SLC7A11) effectively suppresses the proliferation of glutamine-depleted TNBC in vitro and in vivo 60

Animals Study protocols were conducted in male Albino Wistar rats that had a body weight 200250 g, were 12 weeks old and were bred inhouse at the animal facility of the Department of Pharmacology School of Medicine, Zagreb, Croatia

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