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In human cellular models, JEL3108 significantly reduced TNF-alpha, IL-1-beta, and IL-6 markers

These results suggested that keloid fibroblasts underwent pro-senescence regulation earlier compared with normal skin fibroblasts via p53-pS15 under serum limitation stimulus, and p53-pS15 and FOXO4 translocated from the nucleus to the cytoplasm during FOXO4-DRI treatment

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That leaves an Excess Return of US$3.16 per share, which is the profit attributed to shareholders above the modelled required return

The evidence for this theory falls under three categories: statistical analysis, common genetics, and shared medical conditions

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