Nutrients 14, 3115
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It has been studied in laboratory research for its role in skin, tissue, and cellular support
A study generated a new suicide gene/prodrug system showed that specific cancer cells modified to express Tb HGPRT were able to convert the non-toxic allopurinol into cytotoxic metabolites, selectively induced apoptosis in five NSCLC cell lines, one murine lung cancer cell line (M27), and four human NSCLC cell lines (A549, H460, H661, H520)
[6] The concern with any unregulated IGF-1R agonist is precisely that it could stimulate the survival and proliferation of pre-neoplastic or neoplastic cells, which is why IGF-1R has been an oncology drug target for inhibition rather than activation