Endocrine Modulation: DSIP is proposed to interact with hormones such as luteinizing hormone (LH) and growth hormone (GH), potentially contributing to sleep-related endocrine regulation
This multi-pathway approach to reducing inflammation is far more effective than relying on a single compound, especially in cases of chronic or widespread inflammation
Larazotides primary rationale is to reduce this paracellular permeability by stabilizing tight junction complexes and limiting the passage of large, immunogenic molecules from the gut lumen into the bloodstream
That said, sublingual supplementation and intramuscular injections both bypass gastric absorption and may have higher efficacy rates
Chou A-H, Chen S-Y, Yeh T-H, Weng Y-H, Wang H-L
Right now in 2025 there is still not enough high-quality human evidence to call it safe and effective by Australian medical standards