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Additionally, there is a third testis-specific Trx reductase, TrxR3, also known as thioredoxin glutathione reductase, which is primarily expressed in germ cells and contains a class I Grx domain [9] (see below)

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Its relevance to neuropathy is most direct in the metabolic neuropathies, particularly diabetic peripheral neuropathy, where impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction all contribute to nerve damage