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Drug effects: The common element of the mechanism of action of the NPBC is the suppression of the synthesis of prostaglandins from peanut acid by inhibiting the enzyme cyclooxygenase

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Reverce: randomized phase II study of regorafenib followed by cetuximab versus the reverse sequence for metastatic colorectal cancer patients previously treated with fluoropyrimidine, oxaliplatin, and irinotecan