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In an early-stage atherosclerosis model (12-week-old mice receiving 10 weeks of exercise intervention), exercise significantly improved the lipid profile: reducing plasma TC by 16%, free cholesterol by 13%, TG by 35%, and phospholipids by 27%

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Notably, these results suggest that Mcp1 indirectly influences Cap1 activation through mitochondrial oxidative stress signaling rather than through direct binding

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doi: 10.3390/pharmaceutics15071816, 136