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a rapid 1st-phase dissociation of approximately 50% of -receptor bound drug followed by a slow 2nd-phase dissociation
Uplifted GnRH signaling can lead to moderated LH/FSH levels, which may support residual estrogen and progesterone production
doi: 10.1155/2021/9989757 71 ChenWZhengRBaadePDZhangSZengHBrayFet al
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Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy