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Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

There is clear evidence of microvascular injury in the brains of deceased patients with COVID-19, including fibrinogen leakage and thinning of the endothelial cell basal laminae in the olfactory bulb 14,21

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Reproductive research (early-phase): Studied in functional hypothalamic amenorrhea and as an IVF ovulation trigger, where it can induce an LH surge with potentially lower ovarian-hyperstimulation risk than hCG [11]