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Synergy hypothesis: a three-axis model No peer-reviewed study has tested any pairwise combination of GHK-Cu, TB-500, and BPC-157 in vitro or in vivo

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Therefore, drugs can be selected on the basis of the expression pattern of ferroptosis-inducing genes (e.g., SLC7A11, GSH, and GPX) or genes associated with metabolic pathways that affect ferroptosis (e.g., GLUT, PDK4, glutaminase, VDAC, and G6PD)

Iron compounds are also involved in many redox reactions: oxygen transport, cellular oxidative respiratory chain, tricarboxylic acid cycle, and DNA biosynthesis (Thirupathi and Chang, 2019