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2nd Tier Biologics : Tofacitinib (Janus Kinase inhibitor) (often labeled a Targeted Biologic ) and other drugs in this subclass of medications have been found to be as effective as methotrexate, but their relatively higher incidence of biologic side effects for increased infections and cancer risk, as well as other side effects remain a cause for concern when their use is considered

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The Neh3 domain, located at the C terminus, together with Neh4 and Neh5 domains, is responsible for transcriptional activation