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In other words, our glutathione (GSH) requirements remain the same, but the cells stop producing it in the quantities needed because homeostasis has been reached
The most commonly studied approaches to make it more stable are modifying the molecular structure of glutathione into S-acetyl glutathione, S-allyl glutathione, and l-cysteineglutathione mixed disulfide [16,18,20], or co-administering GSH with permeation enhancers (e.g., chitosan, citric acid, cyclodextrins, glycerides, lauryl carnitine chloride, and sodium lauryl sulfate [18]