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Apr 2012;6(2):172-187

Metallothionein, the only known protein implicated in cellular zinc distribution, binds 7 zinc atoms via thiolated ligands

10.1096/fj.08-105726 89 MaggioM.LauretaniF.BasariaS.CedaG.BandinelliS.MetterE.et al

Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status