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The genetic or pharmacological restoration of GPX4 suppresses neutrophil ferroptosis and abrogates downstream autoimmunity, underscoring GPX4 as a checkpoint that constrains iron-driven inflammation (206, 217)

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Stewart CA, Gay CM, Xi Y, Sivajothi S, Sivakamasundari V, Fujimoto J, Bolisetty M, Hartsfield PM, Balasubramaniyan V, Chalishazar MD, Moran C, Kalhor N, Stewart J, Tran H, Swisher SG , Roth JA, Zhang J, de Groot J, Glisson B, Oliver TG, Heymach JV, Wistuba I, Robson P, Wang J, Byers LA