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Proc Natl Acad Sci U S A , 109 (41), 1661816623

Case reports of maternal convulsions and cardiovascular collapse following use of some local anesthetics for paracervical block in early pregnancy (as anesthesia for elective abortion) suggest that systemic absorption under these circumstances may be rapid

More specifically, research shows small peptides under 16 kilodaltons (kDa) primarily leave the injection site through diffusion into blood capillaries, while larger proteins are predominantly absorbed via the lymphatic system