[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Del Rio D, Borges G, Crozier A
Based on the characteristics of low pH and increased ROS in diabetic wounds, a pH/ROS dual-responsive hydrogel has been designed that releases diclofenac sodium and caffeic acid to inhibit inflammation and promote angiogenesis, achieving rapid healing of diabetic wounds in their acidic oxidative environment (Wu et al., 2022b)
USA 108 , 1047210477 (2011)
IFN- is responsible for macrophage activation, enhanced antigen presentation, and induction of nitric oxide-mediated killing mechanisms (Sedgwick et al., 1999)
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However, during oxidative stress, this ratio decreases to 10 (62)