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Hepatic glucagon receptor activation stimulates fatty-acid oxidation, reduces hepatic steatosis, and most importantly raises resting energy expenditure
Allows confirmation that an effect is centrally mediated rather than peripheral
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GWAS efficiently explores biological associations between traits by utilizing global and local genetic correlation analyses to identify shared biology (i.e., pleiotropy) across different traits
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doi: 10.1189/jlb.3A1215-552R 193 CaroppoCPagliaraP
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