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Plasma riboflavin and vitamin B-6, but not homocysteine, folate, or vitamin B-12, are inversely associated with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition-Varese cohort
Because it does not suppress appetite, it can theoretically be combined with GLP-1 agonists to add a lipolytic component to the appetite suppression mechanism, though clinical data on this combination is lacking
In summary, vitamin B12 is essential for many body functions
For a peptide that targets fat metabolism, this degree of systemic safety is notable
It is vital for the production of myelin, the protective sheath that surrounds nerve fibres and enables efficient transmission of nerve signals throughout the body
When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention
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