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alcohol flattens it, lowers testosterone, raises cortisol, and blunts muscle protein synthesis by a quarter to a third

10.1016/j.jtcvs.2005.06.015 J

Prostate 67 , 162171 (2007)

Mechanistically, GSH depletion does not cause global protein oxidation but instead selectively oxidizes and destabilizes fatty acid synthase while decreasing lipogenic gene expression at the transcriptional level, collectively suppressing lipogenesis

Therefore, it would be of interest to investigate whether similar molecular mechanisms involving promiscuous disease-specific intracellular aggregation underlie these disorders as well