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The mechanism of action of IGF-1 LR3 is multifaceted, involving the direct stimulation of muscle cells and other tissues by binding to the IGF-1 receptor, which activates intracellular signaling pathways essential for muscle growth and differentiation

doi: 10.1096/fj.04-2212fje

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NNMT (nicotinamide N-methyltransferase) is upregulated in adipose tissue during obesity and metabolic dysfunction, where it actively depletes NAD+ by converting nicotinamide into N-methyl-nicotinamide for excretion

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