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The process isnt sudden or patchy its a slow reversal as the bodys own pigment production normalizes
Furthermore, our own work, together with that of others, emphasizes that a moderate elevation of circulating homocysteine related to impaired homocysteine metabolism (resulting from folate deficiency or dietary methionine excess) might trigger vascular disorders by promoting vascular spasm and thrombosis (Bellamy et al, 1998
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Table 1 summarizes the kinetic parameters of the enzyme with these different substrates