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Bisubstrate strategies to target methyltransferases

Cells were cultured in a cell incubator containing 5% CO 2 using RPMI-1640 (Gibco, Waltham, MA) medium containing 10% fetal bovine serum (Gibco)

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Exogenous risk factors such as an exposure to ultraviolet light, increase melanoma incidence, as well as skin damage with burns, frostbite and damage after radiotherapy, although the mechanism of the latter is not always clear

The mitochondrial NAD + pool is relatively distinct from that of the rest of the cell

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