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Mesenchymal stem cell therapy can reduce serum amylase and TNF- concentrations, increase serum IL-10 concentrations, reduce brain microvascular endothelial cell apoptosis, up-regulate claudin-5 levels, and reduce MMP-9 levels [57, 68]

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Cardiovascular complications such as endothelial dysfunction, cardiac remodeling, renal alteration, and oxidative stress are associated with hypertension, and these complications worsen with age