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In particular, topiramate may control the flow of glutamate and cysteine through System Xc-, which could impact GSH synthesis and improve the ability of GPX4 to change harmful lipid hydroperoxides into safe lipid alcohols

These findings suggest that the observed trend toward benefit is unlikely to be driven by a single biased study, although the overall certainty of evidence remains limited by imprecision and heterogeneity

Cascella R, et al

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Senescence and the aging immune system as major drivers of chronic kidney disease

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