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Minimum effective frequency is 4 applications per week

These may include injection site discomfort or mild swelling, occasional headache, or mild fatigue, particularly with appropriate dosing and patient preparation including adequate hydration

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Perhaps the most compelling evidence that inflammation plays a causal role in depression comes from immunotherapy studies, where administration of IFN- or IL-2 for treatment of cancer or hepatitis C induces symptoms of depression in a time- and dose-dependent manner [269, 270]