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Glutathione in foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire

11,78 Moreover, suppressing either component of system Xc induces ferroptosis by disturbing cystine uptake, then limiting GSH synthesis

doi: 10.1038/s41419-020-2713-8 115 ZhuZZhangCQianJFengNZhuWWangYet al

First of all, the dual role of the gastrointestinal system - dedicated not only to nutrient absorption from the lumen, but also to their supply to other tissues via the blood - may present one of the reasons for the intestine-specific susceptibility to TD

This limitation is particularly evident in understanding the roles of GRX, GSNO, S-glutatylation, and S-nitrosylation processes

Notably, sulforaphane-induced ROS production is specific to plants