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(2017) investigated AOD9604 in a preclinical model of joint pathology
Guideline 1: Tailoring B12 Therapy to Underlying Causes Effective B12 therapy needs a personalized touch
The standard NHS protocol for B12 deficiency typically involves hydroxocobalamin 1mg intramuscularly three times a week for two weeks (if there's no neurological involvement) or on alternate days until no further improvement (if neurological symptoms are present)
In the case of suspected cobalt hypersensitivity, an intradermal test dose should be administered because anaphylactic shock and death have followed parenteral administration of methylcobalamin
Rak K, Volker J, Jurgens L, et al