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4.0 [Available from: Acknowledgements Technical assistance was provided by Mari Wallbring, Carola Jansson, Ulrika Mattsson and Mathilda Lindholm

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GIP = glucose-dependent insulinotropic polypeptide

Brain section slides were stained with Congo red to evaluate amyloid plaques by averaging the number of plaques in ten different fields under 10x magnification in multiple areas of the brain blindly by two separate observers

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Quickstart Highlights Tirzepatide is a dual GLP-1/GIP receptor agonist it engages two incretin pathways to curb appetite and improve glycemic control [1] and has been studied for substantial weight loss and broad metabolic improvement in obesity and type 2 diabetes [2] [3]