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Although each model differs in terms of CAG repeat length and transgene expression levels, and thus in the severity of the resulting HD phenotype, they were instrumental in demonstrating a fundamental feature of the disease, namely that severe neuronal dysfunction precedes degeneration and it is probably the primary cause of many HD symptoms 8,9

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The lack of treatment options for a burgeoning health problem of this magnitude necessitates that new and innovative therapeutic approaches be developed as quickly as possible

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However, this average hydrodynamic size indicates a colloidal stability appropriate for biomedical applications, corroborated by the PDI value (inset) that evidences a low-moderate dispersion