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Moreover, oral vaccination can stimulate humoral and cellular immune responses at mucosal sites ( A prerequisite for successful oral vaccines is that oral vaccine antigens should be devoured and transported into the mucosa-associated lymphoid tissue (MALT) across the mucosal barrier by Microfold cells (M cells)

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Moreover, the TEM results revealed that the mitochondrial and ER morphological structures were obviously abnormal in the TGF-1 group, as indicated by a notable decrease in ER integrity and an increase in the number of fragmented mitochondria