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A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents

doi.org/10.1210/jc.2005-1536 Mayo, K

Then, they are oxidized to toxic lipid peroxides by LOXs

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