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Its well-characterized pharmacological profile has established 5-Amino-1MQ as a valuable research tool for studying NNMT enzyme biology, enzyme-inhibitor interactions, methylation pathway regulation, nicotinamide-associated metabolic networks, and structure-activity relationships involving NNMT-targeting compounds

Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

Importantly, persistently high serum B12 in the absence of supplementation should prompt GP assessment, as it may indicate underlying disease processes