USP25 is also implicated in inflammation, and it has been found to facilitate removal of Lys63-linked ubiquitin chains from tumor necrosis factor-receptor associated factor 5/6 (TRAF5/6), Usp25 -deficient mice show higher sensitivity to IL-17 dependent inflammation and autoimmunity (Zhong et al., 2012)
doi: 10.3389/fphys.2021.680544 Received 14 March 2021 Accepted 20 August 2021 Published 17 September 2021 Volume 12 - 2021 Edited by Karina Thieme, University of So Paulo, Brazil Reviewed by Nilberto Robson Falco Nascimento, State University of Cear, Brazil
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